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Conversely, at higher concentrations, it tends to accumulate within the nonpolar chains of the phospholipid bilayer ( In vivo studies on rats showed poor absorption of orally administered curcumin, with more than 90% excreted in feces within 72 h ( Plasma concentrations remained minimal, even at high doses, with most curcumin localized in the small intestine and little reaching systemic circulation, resulting in a bioavailability of approximately 1% ( 8.2 Metabolism and elimination of curcumin Curcumin’s bioavailability in humans is mostly limited by poor intestinal absorption, rapid hepatic metabolism, and rapid systemic elimination, even at high doses of 12 g/day ( Figure 4

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Serious adverse effects are rare but have been reported, particularly with IV administration of thiamine